Resistant hypertension after kidney transplantation.

Callus R, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220307 Description A 50-year-old man with known hypertension, diabetes controlled on diet and end-stage kidney disease of unknown aetiology received a donor after brain death renal allograft from an extended criteria donor. There was initial delayed graft function, followed by a reduction in serum creatinine to a nadir of 115 μmol/L. Maintenance immunosuppression included tacrolimus, mycophenolic acid and corticosteroids. Four months following transplantation, he presented with worsening blood pressure control and bilateral lower limb oedema. This occurred despite escalation of antihypertensive medication, which included a calcium channel blocker, loop diuretic, beta-blocker and alpha-blocker. Compliance to treatment was ensured. Ambulatory blood pressure monitoring recorded a mean blood pressure of 168/98 mm Hg with no nocturnal dipping. Serum creatinine at this stage was 130 μmol/L. On introduction of an ACE inhibitor, creatinine rose by approximately 30% to 179 μmol/L. A faint bruit was audible over the allograft. In view of this, CT renal angiography was performed (figure 1). Percutaneous angioplasty and stenting was undertaken (figure 2). Serum creatinine fell to 120 μmol/L after 6 months. Repeat ambulatory blood pressure monitoring gave a mean blood pressure reading of 130/85 mm Hg, although he continued on the same antihypertensive therapy. Transplant renal artery stenosis (TRAS) is a recognised cause of post-transplant refractory hypertension, renal dysfunction and allograft loss. The reported incidence varies from 1% to 23%. 2 Presentation most commonly occurs in the first 6 months following transplantation but may present at a later stage. Hypertension and fluid retention secondary to activation of the renin– angiotensin–aldosterone system are characteristic findings. Prompt diagnosis is crucial since it is potentially curable. Comorbidities associated with TRAS include diabetes mellitus, hypertension, hyperlipidaemia and smoking. Proposed causes include donor or recipient artery atheroma, arterial trauma during procurement or transplantation, different suture techniques with end-to-end anastomosis being more liable to error, immune-mediated vascular damage, prolonged cold ischaemia time and rarely extrinsic mechanical compression. Cytomegalovirus infection and delayed graft function are considered to be risk factors. Duplex ultrasonography is a useful non-invasive screening tool for TRAS; however, it remains operator-dependent and transplant vessels may be difficult to visualise. Indeed, our patient was initially screened with Doppler ultrasound of the allograft; however, it was non-diagnostic in this case. More accurate tools for diagnosis include CT or magnetic resonance angiography. Treatment includes conservative medical therapy, percutaneous transluminal angioplasty (PTA) or surgical therapy. In cases with uncontrolled hypertension, deteriorating renal function or worsening stenosis, revascularisation is advised. PTA with stent Resistant hypertension after kidney transplantation Roberta Callus, Maria Bugeja, Lara Delicata, Adrian Mizzi Images in...